Cotoneaster Manna Effects on Animal Model of Aggression and Depression like Behaviors in the Environment

Shirali Kharamin, Heibatollah Sadeghi Mansoorkhani, Roggayeh Kharamin, Rezvan Babamir, Hashemi Mohammad Abad Nazir

Ekoloji, 2019, Issue 107, Pages: 175-181, Article No: e107006


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Objective: complementary medicine (CAM), especially herbal medicine, is widely used in worldwide. Although use of herbal medicine among patients with mental disorders seems common, limited scientific data exist about the efficacy, side effects and safety of these herbs. In other hands, there are also concerns about the possible negative psychiatric effects. Cotoneaster manna, as an herb, has been used pervasively in traditional and modern medicine for treatment of physical disorders as therapeutic and protective medicine. This study was established to assess domestic common believes and concerns (especially psychiatric problem side effects) about this herb and also assess its effects on animal model of aggression and depression Methods and materials: in this experiment 24 male Albumin Wistar rats were divided to three groups, control, treatments (500 and 1000 mg/kg) and Bilineaster herbal oral drop (Cotoneaster manna drop) was gastrogavaged for five days. Resident intruder paradigm, chronic mild stress, and the forced swim test were administrated and data were calculated according to protocols. Results: ANOVA revealed a significant difference between three group in both of swimming (p=.002) and mobility (p=.004) with higher scores for treatment groups. There was no significant difference between three groups in offensive aggressive behavior and social exploration behaviors in the environment (p>.05). Conclusion: The result showed that Cotoneaster manna not only increased anti-depressive like behaviors, but also does not induce any aggressive behavior in the environment.


animal model, aggression, depression, cotoneaster


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